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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Study: Comparing treatments for rectal cancer before surgery and observation.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at two different treatments for rectal cancer. Rectal cancer is when cancer cells grow in the last part of the large intestine. It checks if using chemotherapy (strong medicine that kills cancer cells) before surgery works as well as using both chemotherapy and radiation therapy (high-energy rays to kill cancer cells) before surgery. It's also studying if quality of life is better without radiation.

Usually, people get surgery to remove the cancer or get chemotherapy and radiation before surgery. In this study, you will get either just chemotherapy for up to 12 weeks or both chemotherapy and radiation for about 6 weeks. After treatment, doctors will decide on the best surgery and check on you often for up to 5 years.

  • This study lasts around 5 years with regular check-ups.
  • Participants might get different types of treatment before surgery.
  • There are specific health requirements to join.

Joining this study could help doctors learn better ways to treat rectal cancer and might improve your quality of life.

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Study details
    Rectal Cancer

NCT06205485

Canadian Cancer Trials Group

14 June 2025

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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