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Safety, Tolerability, and Pharmacokinetics of KarXT and Dual-burst Release of Xanomeline With Immediate-release Trospium Chloride in Adolescents With Psychiatric Disorders

Studying safety and effects of KarXT in teens with psychiatric disorders.

Recruiting
13-17 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for teens with psychiatric disorders like schizophrenia or ADHD. It looks at the safety and effects of a new medicine called KarXT. KarXT is a mix of two drugs: xanomeline and trospium chloride. Xanomeline helps brain signals, and trospium chloride helps control side effects. Participants will take these drugs in different ways and amounts to see how their bodies react. Teens need to be stable in their condition to join. Some conditions, like serious heart or liver problems, make them ineligible.

  • Study involves multiple doses and check-ups.
  • Participants must be clinically stable.
  • Teens with serious health issues may not join.
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Study details
    Psychiatric Disorders

NCT06853171

Bristol-Myers Squibb

17 May 2025

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