This study tests a medicine called **lorundrostat** for people with obstructive sleep apnea (OSA) and high blood pressure. OSA is a condition where breathing stops and starts during sleep. High blood pressure, also called hypertension, is when the force of blood against your artery walls is too high. The study checks how well this medicine works and if it's safe. People taking part will be between 18 and 75 years old and have moderate to severe OSA. They should also have high blood pressure and meet other study rules. Participants will take the medicine or a placebo (a fake pill that looks like the real medicine) for two 4-week periods with a 2-week break in between. Some people in the study will use a machine called a CPAP or autoPAP, which helps them breathe at night. To join, you need to have a **body mass index** (BMI) of at least 27, which means you might be overweight. The study lasts several weeks, and you will visit the doctor for check-ups.

• The study lasts around 10 weeks, including the washout period.
• Participants will have regular doctor visits.
• Participants taking part will not know if they receive lorundrostat or placebo.