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Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

Study testing Ravulizumab's effects on kidney transplant recovery.

Recruiting
18 years and older
All
Phase 3

This study is checking if a medicine called *ravulizumab* can help people who have a kidney transplant. When you get a kidney from someone who has died, sometimes the new kidney doesn't work right away. This problem is called **Delayed Graft Function (DGF)**. The study wants to see if *ravulizumab* can make the new kidney work faster so people don't need dialysis, which is a treatment that cleans your blood.

Participants will get either *ravulizumab* or a fake medicine (a placebo) through a needle in their vein (intravenously). It's a double-blind study, which means neither the participants nor the doctors know who gets the real medicine or the placebo.

  • Participants must be 18 or older and need a kidney transplant because of severe kidney disease.
  • The study is for those getting kidneys from specific types of donors.
  • You can't join if your kidney donor has certain conditions or if you have a severe kidney injury.
Study details
    Delayed Graft Function
    DGF
    Kidney Transplant

NCT06830798

Alexion Pharmaceuticals, Inc.

12 July 2025

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