This study is testing a new medicine called **tonlamarsen** to see if it can help lower blood pressure in adults. Some people have **uncontrolled hypertension**, meaning their blood pressure (BP) is too high even though they're taking at least two BP medicines. This study is for people aged 18 to 80 who are already on 2 to 5 BP medicines but still have high BP, between 135 and 170 mmHg. People with other health issues like **secondary hypertension** (high BP caused by another condition), heart problems, or thyroid issues can't join. If you're interested, here are 3 things to think about:

• **Length of Study**: Consider how long you'll be part of the study.
• **Visits Needed**: Think about how many times you'll need to visit the doctor's office.
• **Risks and Treatment**: Be aware of potential risks and the new treatment involved.