**Avexitide for Treatment of Post-Bariatric Hypoglycemia** This study looks at a medicine called avexitide to help people with low blood sugar (hypoglycemia) after they've had a type of weight-loss surgery called Roux-en-Y gastric bypass (RYGB). It compares avexitide to a fake treatment (placebo) to see if it helps reduce low blood sugar events safely. Participants need to have had RYGB surgery at least a year before joining the study and must follow a special diet. The study lasts for about 54 weeks and includes different parts: a 6-week screening, a 16-week main study where neither the participants nor the researchers know who gets the real medicine, and a 32-week period where everyone knows they are getting avexitide. Participants will use devices to check their blood sugar and record events. **Key Points:** - The study involves a commitment of up to 54 weeks, including different phases. - Participants will use devices like a glucose meter and electronic diary to monitor their blood sugar. - Participants must follow dietary guidelines and maintain a stable weight.