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A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

Comparing Elacestrant to standard treatment for high-risk breast cancer.

Recruiting
18 years and older
All
Phase 3

This study is testing a new medicine called elacestrant against regular hormone treatment for breast cancer. The focus is on people with early breast cancer that might come back, and they have a special type of cancer called ER+ (Estrogen Receptor-positive) and HER2- (Human Epidermal Growth Factor-2 negative). The study wants to see if elacestrant works better. People can join if they have a type of breast cancer that is positive for estrogen but not for HER2, have been on hormone therapy for 2-5 years, and are at a high risk of their cancer coming back. They cannot participate if they have had other types of breast cancer or other cancers recently. This study helps us learn more about which treatment is best for keeping breast cancer from returning.

  • Participants must have a type of breast cancer that has a high risk of coming back.
  • The study lasts until either treatment stops working or it is no longer safe.
  • People will be compared between those receiving elacestrant and those on standard therapy.
Study details
    Breast Cancer

NCT06492616

Stemline Therapeutics, Inc.

3 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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