This study is testing if a new drug, TMP-301, is safe and helps reduce alcohol consumption in adults with Alcohol Use Disorder (AUD). AUD is a condition where a person struggles to control their alcohol intake. TMP-301 has been tested before and found safe in healthy people. This study will compare TMP-301 to a placebo, which is a harmless pill used to see if the real drug works better. Participants must be 18-65 years old and have had at least 8 days of heavy drinking in the last month. The study lasts up to 19 weeks, with 14 weeks of treatment and weekly visits to the study center.

• Expect weekly visits for up to 19 weeks.
• You can't participate if you have certain health conditions or take specific medications.
• Participants must agree to use effective birth control during the study.

**Note**: Heavy drinking is defined as 4 or more drinks for women and 5 or more drinks for men in one day. If interested, ensure you meet the study's health and lifestyle requirements before joining.