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A Trial to Evaluate Tolerability and Immunogenicity of V540D in Healthy Adults (V540D-004)

Study on V540D vaccine safety and immune response in healthy adults.

Recruiting
18-45 years
All
Phase 1

Researchers are testing a new vaccine, called V540D, to see if it can protect against more types of HPV (human papillomavirus) than the current vaccine, GARDASIL®9 (G9). HPV is a virus that can sometimes lead to cancers, although most people’s immune systems can fight it off. The main aim is to check if V540D is safe and if people can tolerate it well.

Eligibility: To join, you must be in good health as shown by a health check, including tests like ECGs (which checks your heart). You cannot join if you've had abnormal Pap smears, HPV-related genital issues, or cancer. Also, if you've already had an HPV vaccine or plan to get one outside the study, you cannot participate.

  • The study involves healthy adults who have not received an HPV vaccine.
  • Participants will undergo medical examinations to ensure they are healthy.
  • The study focuses on the safety and tolerance of the new vaccine V540D.
Study details
    Healthy

NCT06688058

Merck Sharp & Dohme LLC

19 July 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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