This study is looking at new ways to treat early-stage endometrial cancer, a type of cancer that starts in the lining of the uterus. The study focuses on two groups: those with a specific change in their DNA called POLE-mutated and those with p53 wildtype/NSMP (no specific molecular profile). The usual treatment for this cancer involves surgery to remove the uterus (hysterectomy) and ovaries, followed by tests to see if more treatment is needed. This study wants to see if a different approach works better.

Key Points:

• Participants need to have had surgery already and should start study treatment within 10 weeks after surgery.
• Participants must be at least 18 years old and willing to answer questions about their health in English, French, or another approved language.
• Participants should not have had certain treatments before, like chemotherapy or pelvic radiation for this cancer.