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Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

Exploring Nivolumab with standard treatment for advanced stomach/esophageal cancer.

Recruiting
18 years and older
All
Phase 2/3

This study is testing if adding nivolumab, a special protein called a monoclonal antibody, to standard cancer treatments paclitaxel and ramucirumab helps people with advanced stomach or esophageal cancer. Nivolumab may help the body's immune system fight cancer. Ramucirumab stops new blood vessels from growing, which tumors need. Paclitaxel helps stop cancer cells from growing. The study will check if adding nivolumab helps people live longer without the cancer getting worse.

  • The study lasts up to 3 years with follow-ups every 6 months.
  • Participants will receive treatments through a vein (IV) and need regular scans.
  • Participants must have specific cancer types and meet health requirements to join.

It's important for participants to have regular check-ups and scans. They must not have certain health issues, like major recent surgeries or untreated infections. This study aims to improve treatment for advanced cancer patients by testing a combination of existing and new therapies.

Study details
    Advanced Esophageal Adenocarcinoma
    Advanced Gastric Adenocarcinoma
    Advanced Gastroesophageal Junction Adenocarcinoma
    Clinical Stage II Esophageal Adenocarcinoma AJCC v8
    Clinical Stage III Esophageal Adenocarcinoma AJCC v8
    Clinical Stage III Gastric Cancer AJCC v8
    Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
    Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
    Clinical Stage IV Gastric Cancer AJCC v8
    Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
    Metastatic Esophageal Adenocarcinoma
    Metastatic Gastric Adenocarcinoma
    Metastatic Gastroesophageal Junction Adenocarcinoma
    Unresectable Esophageal Adenocarcinoma
    Unresectable Gastric Adenocarcinoma
    Unresectable Gastroesophageal Junction Adenocarcinoma

NCT06203600

National Cancer Institute (NCI)

10 May 2025

Step 1 Get in touch with the nearest study center
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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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