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Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer

We're comparing two scans to study radiation effects on head and neck cancer.

Recruiting
18 years and older
All
Phase N/A

This study is comparing two types of scans to see their effects on blood vessels in the neck for patients receiving radiation therapy for head and neck cancer. The standard scan uses a substance called F-18 FDG and combines PET (positron emission tomography) and CT (computed tomography) scans to create detailed images. Another type of scan being tested uses F-18 NaF, which might offer a better view of changes in blood vessels. Radiation therapy, aimed at treating cancer, can affect the neck's blood vessels that supply blood to the brain. The study has two parts: one for patients receiving a type of radiation called IMRT and another for IMPT. The aim is to see if the F-18 NaF PET/CT scan works as well or better than the standard scan. This study involves a few visits for imaging and requires adult patients who are undergoing radiation therapy for certain types of head and neck cancer.

  • Duration: Imaging done before and 12 weeks after radiation therapy.
  • Eligibility: Adults 18+, specific cancer stages, and treatment plans.
  • Exclusions: Pregnant women, recent chemotherapy, and severe heart issues.
Study details
    Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
    Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
    Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
    Head and Neck Squamous Cell Carcinoma
    Hypopharyngeal Squamous Cell Carcinoma
    Laryngeal Squamous Cell Carcinoma
    Oropharyngeal Squamous Cell Carcinoma
    Stage III Hypopharyngeal Carcinoma AJCC v8
    Stage III Laryngeal Cancer AJCC v8
    Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
    Stage IVA Hypopharyngeal Carcinoma AJCC v8
    Stage IVA Laryngeal Cancer AJCC v8
    Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8
    Stage IVB Hypopharyngeal Carcinoma AJCC v8
    Stage IVB Laryngeal Cancer AJCC v8
    Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8

NCT06914999

Emory University

12 April 2025

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