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A Study of GC012F (AZD0120), a CAR T Therapy Targeting CD19 and BCMA in Subjects With Relapsed/Refractory Multiple Myeloma

Exploring CAR T therapy for relapsed/refractory multiple myeloma patients.

Recruiting
18 years and older
All
Phase 1/2

This study is for adults with Relapsed/Refractory Multiple Myeloma, a type of blood cancer that returns after treatment. The treatment, called GC012F (AZD0120), is a special kind of therapy known as CAR T-cell therapy. It targets two proteins, CD19 and BCMA, on the cancer cells to help fight the disease.

The study has two phases. In Phase 1b, it checks how safe the treatment is and how it behaves in the body. Phase 2 looks at how well the treatment works and how it affects patients' health and quality of life.

  • Participation: You must be 18 or older, with at least three prior treatments for multiple myeloma.
  • Study Length: The study involves multiple visits to the study doctor to monitor health and response to treatment.
  • Risks: Potential side effects include reactions from the therapy, and your heart health will be checked.

Discuss with your doctor if you meet the criteria and are interested in joining. The study aims to improve treatment for those with few other options.

Study details
    Relapsed/ Refractory Multiple Myeloma

NCT05850234

AstraZeneca

21 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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