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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

Researching Tezepelumab's effects on adults with moderate to severe COPD.

Recruiting
40-80 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)
Study Overview: This study is looking at a medicine called tezepelumab to see if it helps people with a lung disease called Chronic Obstructive Pulmonary Disease (COPD). COPD makes it hard to breathe and can get worse over time. This study is for adults aged 40-80 who have moderate to very severe COPD and have had flare-ups in the last year. How It Works: Participants will either get tezepelumab or a placebo (a pretend medicine) through monthly injections for about 1 to 1.5 years. A placebo is used to help compare the effects of the real medicine. After stopping the medicine, there will be a 12-week period to check on participants' safety. Key Points:
  • Participants will need to visit the study center regularly over a period of up to 76 weeks.
  • Participants must have had recent COPD flare-ups and be on certain COPD therapies.
  • The study will assess both the effectiveness and safety of the medicine.
Please contact the study team if you have COPD and are interested in participating.
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Study details
    Chronic Obstructive Pulmonary Disease (COPD)

NCT06878261

AstraZeneca

13 June 2026

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