This study is testing a medicine called tezepelumab for people with Chronic Obstructive Pulmonary Disease (COPD). COPD is a lung problem that makes it hard to breathe. If you're 40-80 years old, have COPD, and have had flare-ups, you might be able to join. The study checks if tezepelumab is safe and works well. Participants will get a shot of tezepelumab or a placebo (a fake treatment) once a month for up to 76 weeks. After the treatment, there's a 12-week period to make sure everything is safe.

• Participation lasts up to 88 weeks (76 weeks of treatment, 12 weeks follow-up).
• Monthly clinic visits for injections.
• Possible side effects due to treatment.

People with other lung diseases, asthma, or certain health problems can't participate. Current or past smokers (10+ pack-years) are eligible. This study helps find better treatments for COPD, so consider joining if you qualify.