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A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

A study comparing treatment options for specific colorectal cancer patients.

Recruiting
18 years and older
All
Phase 3

This study looks at two treatments for colorectal cancer, which affects the colon or rectum. Participants have a specific type of cancer called KRAS/NRAS and BRAF wild-type, which means their cancer does not have certain genetic mutations. The study compares two groups: one group will receive a new drug called amivantamab along with a chemotherapy mix called FOLFIRI (includes 5-fluorouracil, leucovorin, and irinotecan); the other group will receive either cetuximab or bevacizumab with FOLFIRI. Researchers will observe how long it takes for the cancer to progress and how long participants live.

  • Study Duration: Participants will be monitored over several months.
  • Visits Needed: Regular visits to the study center are required.
  • Risks: Possibility of side effects from the drugs, like allergies or lung issues.
Study details
    Colorectal Neoplasms

NCT06750094

Janssen Research & Development, LLC

31 May 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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