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Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

Testing a new HIV vaccine's safety in healthy adults.

Recruiting
18-55 years
All
Phase 1

This clinical trial is looking at the safety and how well a new vaccine works in healthy adults aged 18-55 who do not have HIV. The study involves a priming dose of the vaccine followed by booster doses. "Adjuvanted" means something is added to the vaccine to help it work better. The study aims to see if the booster helps the body make strong antibodies, which are proteins that fight infections.

To join, participants must be in good health, not pregnant, and not have HIV. They must agree to use birth control and attend all clinic visits. The study will measure blood pressure, test for diseases like hepatitis, and check for overall good health.

  • Participants will visit the clinic several times for follow-ups.
  • Compensation may be provided for time and travel.
  • Potential risks include common vaccine side effects like soreness or mild fever.
Study details
    HIV

NCT06796686

National Institute of Allergy and Infectious Diseases (NIAID)

31 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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