Study Overview: This study is testing three special antibodies (proteins that help fight infections) called VRC07-523LS, PGT121.414.LS, and PGDM1400LS. These antibodies will be given through an IV (a tube in your vein) to adults who do not have HIV. The goal is to ensure these antibodies are safe and comfortable for the participants. The study will last about 18 months and include 200 participants.

• **Commitment**: Participation lasts 18 months.
• **Requirements**: Regular visits to the clinic are needed.
• **Eligibility**: Participants must be between 18-65 years old and meet health criteria.

Who Can Join? Participants should be healthy adults aged 18 to 65. They must agree to follow the study schedule and not join other clinical trials during this study. They should also be open to talking about HIV prevention and have low risk of getting HIV.

Considerations: Participants cannot join if they have certain health issues, like recent blood transfusions or if they're pregnant. They should not take certain medicines or have allergies to the study products. Participants need to commit to using birth control if needed and will receive regular health check-ups.