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A Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed ES-SCLC Patients in Combination With Carboplatin, Etoposide and Atezolizumab

Testing [177Lu]Lu-DOTA-TATE for new ES-SCLC patients with other treatments.

Recruiting
18 years and older
All
Phase 1/2

This study investigates a new treatment for people with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing cancer. The study tests a drug called [177Lu]Lu-DOTA-TATE along with other drugs: carboplatin, etoposide, and atezolizumab, to see if it's safe and how well it works. The study has three parts: screening, treatment, and follow-up. During screening, doctors check if your cancer has somatostatin receptors (SSTR). Treatment includes an initial phase to find a safe dose and a later phase where participants are randomly assigned to receive the new treatment combination or the standard combination.

  • The study lasts several months, including multiple treatment cycles and follow-ups.
  • Participants must be at least 18 years old and have not had certain treatments before.
  • There may be risks, like side effects from the drugs, and you cannot join if you have other serious health issues.

Before joining, you’ll need to provide a tissue sample and sign a consent form. This study could offer a new hope for treating ES-SCLC, but it’s important to consider the potential risks and time commitment. Consult with your doctor to determine if this study is right for you.

Study details
    Extensive Stage Small Cell Lung Cancer

NCT05142696

Novartis Pharmaceuticals

26 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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