**Early Feasibility Study of "HyperQureTM RDN System"** **HyperQureTM RDN System** is being tested to see if it is safe and works well. This system uses *laparoscopic renal denervation*, a way to help people with **resistant hypertension** (high blood pressure that doesn't get better with medicine). This study will involve 15 adults who have this type of high blood pressure and are taking at least three different blood pressure medicines. Participants will have a special procedure done while they are asleep (under *general anesthesia*). The study will last for 36 months, during which participants will have their blood pressure checked in different ways and undergo imaging tests. - **Key Points to Consider:** - **Study Length:** 36-month follow-up period. - **Procedure:** Requires general anesthesia and laparoscopic surgery. - **Eligibility:** Participants must have resistant hypertension and meet other specific health criteria. This study helps scientists see if the new system can reduce high blood pressure more effectively and safely than current methods. Participants should be ready for a long-term commitment and various health assessments throughout the study period.