**Study Purpose**: This study aims to test a new treatment called BMS-986470 for people with Sickle Cell Disease (SCD) and healthy volunteers. The study will check how safe this treatment is, how the body processes it, and its early effects on the disease. **Who Can Join?**: - For Healthy Volunteers: Adults not able to have children, with a healthy body weight, and no major health issues. - For SCD Patients: Those with Sickle Cell Disease who have had several pain episodes recently. **Who Can't Join?**: - Anyone with serious health problems or recent surgeries. - SCD patients with too many severe pain episodes or lung problems recently. **Key Points for Participants**: - **Length of Study**: You will need to stay in the study for a certain period, as defined by the research team. - **Visits and Tests**: There will be several visits and health assessments needed. - **Safety**: The study is focused on keeping you safe while testing the treatment. This study is important for finding new ways to help people with Sickle Cell Disease feel better.