The study is testing a new treatment called **Neural Ice** to see if it helps with knee pain from osteoarthritis, a condition where the knee joint wears down. This study is for adults aged 22-80 who have tried other treatments without success. Participants will visit the study site, keep a diary, and be followed for six months after treatment. Some people cannot join, like those with allergies to certain substances or history of specific health conditions. **Key Points:** - **Duration:** Follow-up lasts 6 months. - **Visits:** Participants need to attend various study visits and complete a diary. - **Exclusions:** Not suitable for those with certain allergies or specific health conditions. Participants need to agree to see only one doctor for knee pain during the study and must be able to understand and sign a consent form. To be eligible, they should have a pain level of 5 or more on a scale, despite other treatments, and have tried treatments like physical therapy without relief.