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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

Studying new first-line treatments for advanced lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is for a type of lung cancer called metastatic squamous non-small cell lung cancer (mNSCLC). "Metastatic" means the cancer has spread, and "squamous" is a type of cell in the lungs. The trial tests two treatments: rilvegostomig and pembrolizumab, both with chemotherapy. Chemotherapy is a treatment that uses strong medicine to kill cancer cells. The study wants to see which treatment works better and is safer for patients whose tumors have a protein called PD-L1. This protein helps cancer hide from the body's defense system.

Here are three key points:

  • Participants will be randomly assigned to one of two groups to receive a treatment.
  • The study will take place in multiple locations around the world and is estimated to last several months.
  • Participants must meet specific health criteria, and compensation may be available.

People with certain health conditions, past treatments, or certain other cancers may not qualify. It's important to discuss with a doctor to see if joining is a good idea.

Study details
    Non-small Cell Lung Cancer

NCT06692738

AstraZeneca

10 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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