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A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer

Examining new treatments for low-grade serous ovarian cancer.

Recruiting
18 years and older
Female
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new combination of drugs—avutometinib, defactinib, and letrozole—to see if they can help treat a type of cancer called low-grade serous ovarian cancer (LGSOC). Researchers also want to check if this treatment is safe.

In order to join, participants need to meet certain criteria, such as being a female aged 18 or older, having certain levels of health, and not having had major surgeries recently. They also cannot take part if pregnant or breastfeeding, or if they have certain medical conditions that could make the treatment unsafe for them.

  • Study Length: Participation includes taking medicine and regular check-ups.
  • Safety Check: This study aims to ensure the treatment is safe.
  • Eligibility: Participants must meet specific health requirements.

Overall, this study is for women with LGSOC who want to try a new treatment option. Participants will have regular doctor visits to monitor their health.

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Study details
    Low-Grade Serous Ovarian Cancer

NCT06394804

Memorial Sloan Kettering Cancer Center

2 August 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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