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Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity

Exploring ways to manage diabetes through different glucose effects.

Recruiting
18 years and older
All
Phase 4

This study focuses on a type of diabetes called ketosis-prone diabetes (KPDM) that often affects African Americans. KPDM is a mix of type 2 diabetes and diabetic ketoacidosis (DKA). DKA is a serious condition where the body produces high levels of blood acids called ketones. The study aims to understand how blood sugar changes day by day during treatment to help patients go into remission, which means the diabetes symptoms get better or disappear. Researchers believe that a process called glucotoxicity, where high blood sugar harms the pancreas, plays a role in KPDM. They will use a continuous glucose monitor (CGM) to track patients' blood sugar and adjust insulin treatment, if needed, to better understand and predict remission.

  • **Duration:** The study will monitor patients from hospital discharge until insulin therapy is stopped.
  • **Visits:** Participants will have a CGM placed upon hospital discharge.
  • **Risks:** Participants will be monitored closely to ensure safe insulin adjustments.
Study details
    Ketosis Prone Diabetes

NCT06699810

Emory University

30 March 2025

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