The MATIC-2 study is a research project looking at ways to help kids who have had serious bleeding because of an injury. **Hemorrhagic shock** means the body doesn't get enough blood, which can be very dangerous. The study tests two things: Low Titer Group O Whole Blood (LTOWB), which is a type of blood transfusion, and **Tranexamic Acid** (TXA), a medicine to stop bleeding. They're comparing LTOWB to regular blood components and TXA to a fake medicine (placebo). The goal is to see if kids are less likely to die within 24 hours if they get these treatments.

• The trial is for kids under 18 with serious bleeding.
• This study is testing new ways of giving blood and stopping bleeding.
• It checks if these treatments make kids safer and help them survive.