This study looks at how well a medicine called dupilumab works for adults with prurigo nodularis (PN), a skin condition that causes itchy bumps. The goal is to see how people use dupilumab in real life to manage PN. The study will also gather information about the patients' medical backgrounds and how effective the treatment is over a long period. The study will last up to 36 months (3 years) or until participants can no longer continue. To join, you need to be 18 or older, have already decided with your doctor to use dupilumab for PN, and be able to understand the study questions. You cannot join if you have a reason that makes dupilumab unsafe for you, struggle to complete the study, or have been on dupilumab in the past 6 months. Also, you can't join if you're already in another clinical trial.

• The study lasts up to 36 months.
• Participants must be 18 years or older.
• Participants must not have used dupilumab in the past 6 months.