Study Summary: This research is about testing two medicines, retatrutide and tirzepatide, for adults with obesity. Obesity means having too much body fat, which can lead to health problems. The study will check how well these medicines work and if they are safe. It will last around 89 weeks, which is a little over a year and a half.

Eligibility: To join, you must have tried to lose weight before without success. You cannot join if you had big weight changes recently, had obesity surgery, or used weight loss drugs in the last three months. Also, if you have a history of certain types of cancer or heart issues, you cannot participate.

• The study will last about 89 weeks.
• Participants must have tried and failed to lose weight before.
• People with recent weight changes or certain health issues cannot join.