This study, called BOOMBOX, looks at using the HistoSonics Edison System to treat liver tumors. **Liver tumors** are abnormal growths in the liver. **Histotripsy** is a way to break down these tumors using sound waves. The study will see how well histotripsy works within 36 hours after treatment and follow patients for up to 5 years to check on their health. It's an **observational study**, meaning doctors watch and collect data without changing standard care. Patients can join sub-studies that look at specific questions or groups, but these have stricter rules.

Eligibility: Participants must be 22 or older, agree to the study rules, and have liver tumors treatable by histotripsy. Pregnant or nursing women and those in other trials cannot join.

• The study may last up to 5 years, depending on individual follow-up needs.
• Participants won't get extra treatments but will have regular check-ups.
• It's safe as it's based on regular medical care without extra procedures.