This study is for adults who are overweight or obese and have at least one weight-related health issue, like high blood pressure. Obesity means having a Body Mass Index (BMI) of 30 or more, while overweight means a BMI of 27 or more. BMI is a number that shows if someone is a healthy weight for their height. The study tests a drug called AZD6234, given as a shot once a week for 36 weeks, to see if it helps with weight loss.

The study has three parts: a screening period of up to 28 days to see if you can join, a treatment period of 36 weeks where you get the shots, and a follow-up period after the last shot to see how you're doing. A total of 231 people will be involved, and they will be randomly chosen to get either the drug or a placebo (a fake shot that does nothing).

• Study lasts around 9 months with weekly visits.
• Participants must have stable weight for 3 months before starting.
• Certain health conditions or recent weight-loss treatments may disqualify you.