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Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM)

Trial for severe autoimmune diseases using SC291 treatment.

Recruiting
18-75 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for adults aged 18 to 75 with severe autoimmune diseases like systemic lupus erythematosus (SLE) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In these diseases, the immune system attacks the body's own cells. The study tests a new treatment called SC291 to see if it's safe and works well. Patients will get a single dose of SC291 after they take medicines called cyclophosphamide (CY) and fludarabine (FLU) to prepare. Candidates for the study must not have had previous treatments that change cells, like CAR T therapy.

  • The study includes a single dose of SC291.
  • Participants should not have had certain previous cell therapies.
  • Study targets severe cases that didn't respond to other treatments.
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Study details
    Lupus Erythematosus
    Systemic Lupus Erythematosus
    SLE (Systemic Lupus)
    Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    Granulomatous Polyangiitis
    Microscopic Polyangiitis

NCT06294236

Sana Biotechnology

19 April 2025

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