Cystic Fibrosis (CF) is a condition that affects the lungs and digestive system. This study, called REACH, is for people with CF who can't take certain medicines called *CFTR modulators*. These modulators help many people with CF, but not everyone can use them. REACH aims to collect health information from people who don't use these modulators. This can help scientists create new treatments and improve clinical trials for these individuals.

The study is *observational*, which means it doesn't involve trying new drugs. Instead, it gathers data over time. Participants must be at least 12 years old and willing to follow the study schedule. They should not be pregnant or planning to become pregnant during the 12-month study.

• The study lasts 12 months and involves regular visits.
• Participants should not start any new long-term therapies or take certain drugs before the study.
• No compensation is mentioned, but the study offers a chance to contribute to future CF treatments.