This study is for people who had their bladder removed because of cancer. Doctors want to see if a special blood test can tell if these patients need extra treatment to stop cancer from coming back. The test looks for **ctDNA**, which is DNA from cancer cells floating in the blood. If ctDNA is found, patients might get **immunotherapy**. Immunotherapy uses **nivolumab** and **relatlimab** to help your immune system fight cancer. The study checks if these medicines help patients live longer without cancer returning.

• The study lasts up to 12 cycles of treatment, each cycle is 28 days.
• Participants will visit the clinic for blood tests and scans.
• There might be risks of side effects from the treatments.

If you had bladder cancer and surgery, and meet specific health conditions, you might be eligible. You should have a certain type of cancer, meet health criteria, and not have had certain previous treatments. Talk to your doctor to see if this study might be right for you!