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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

Exploring new treatment for advanced lung cancer with extra MET gene copies.

Recruiting
18 years and older
All
Phase 2

This study is for people with advanced non-small cell lung cancer (NSCLC) with extra copies of the MET gene in their tumor. The drug being tested is called amivantamab-vmjw. It aims to stop the cancer from growing or spreading by targeting these extra gene copies. Participants will receive amivantamab through an IV (a method of delivering medicine directly into a vein) over several weeks and will have regular CT or MRI scans to check progress. After finishing the treatment, participants will be followed up for up to 3 years.

Key Points to Consider:

  • The study involves receiving medicine via IV and regular scans for progress.
  • Participants must meet specific medical criteria, including previously trying other treatments.
  • After treatment, follow-up will continue for up to three years.

Participants must have measurable disease, confirmed diagnosis of NSCLC with MET amplification, and meet other health criteria. This trial is investigational, meaning it's still being tested, so participants must sign a consent form acknowledging this. If you fit the criteria and agree to join, you'll help researchers learn more about treating this type of cancer.

Study details
    Lung Non-Small Cell Carcinoma

NCT06116682

SWOG Cancer Research Network

31 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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