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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

Trial for advanced lung cancer with extra MET gene copies.

Recruiting
18 years and older
All
Phase 2

This study tests how well a drug called amivantamab-SC works for patients with a type of lung cancer called non-small cell lung cancer (NSCLC) that has extra copies of the MET gene. The MET gene is part of your DNA, and when it copies too much, it can make cancer grow or spread. The drug aims to reduce these extra copies and help stop the cancer from getting worse. In this study, patients receive the drug as a shot under the skin on certain days of the treatment cycle. They will have cycles of treatment every 28 days as long as the cancer doesn’t get worse or they don't experience bad side effects. Patients will also have regular scans like CT or MRI and give blood samples. The study lasts up to 3 years, including follow-ups.

  • Study Duration: Each treatment cycle is 28 days; follow-up for up to 3 years.
  • Visits Needed: Regular check-ups and scans during the trial.
  • Potential Risks: Side effects of the drug and regular blood tests.
Study details
    Lung Non-Small Cell Carcinoma

NCT06116682

SWOG Cancer Research Network

31 March 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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