This study is designed to see if better skin care can help reduce skin problems, like rashes and nail issues, in people with a specific type of lung cancer called **Epidermal Growth Factor Receptor (EGFR)-mutated Non-Small Cell Lung Cancer (NSCLC)**. People with this type of lung cancer often get treated with special medicines like **amivantamab** and **lazertinib**. The study will compare two groups: one will get standard skin care and the other will receive enhanced skin care to see which is more effective in preventing skin issues. A sub-study will focus on those who develop significant skin issues during treatment.

• Participants must be diagnosed with advanced lung cancer and have specific gene mutations.
• The study involves a comparison between enhanced dermatologic care and standard care.
• Participants in the sub-study will have additional focus on treating ongoing skin issues.

This study helps understand which skin care method works best for patients receiving these cancer treatments. Being part of this study means following certain rules and meeting specific health criteria. If you have other health conditions, especially skin-related, it may affect your participation.