This study is testing whether memantine, a medication, can help protect the brain during radiation therapy, a treatment using high-energy rays to kill cancer cells. The study includes children aged 4-18 with primary central nervous system (CNS) tumors, which are growths in the brain or spine. Memantine is thought to possibly help with cognitive functions like attention and memory during brain radiation therapy. Patients will be randomly placed in one of two groups: one receiving memantine and the other a placebo (a sugar pill with no medicine). Both groups will take pills for 6 months and complete memory tests and MRI scans, which use magnets and computers to take pictures of the brain, over a period of up to 48 months.
- Participation lasts up to 48 months, with regular check-ins.
- Memantine is compared to placebo to see which helps better with memory.
- Potential risks include side effects from the medication or radiation therapy.
How understandable was the trial content above?
Hard to understand
Easy to understand