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Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Testing Optune and radiation therapy for children's brain tumors.

Recruiting
3-21 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study tests the Optune device for kids with two types of brain tumors: High-Grade Glioma (HGG) and Diffuse Intrinsic Pontine Glioma (DIPG). The Optune System creates electric fields that can stop tumor growth. In Stratum 1, the study checks if the device can be used safely for kids with HGG or ependymoma. In Stratum 2, it combines Optune with Radiation Therapy (RT) to see if it helps children with DIPG.

  • Kids must wear the Optune for at least 18 hours a day.
  • The study can last up to 5 years, with regular checkups.
  • Patients must have certain health conditions that allow them to participate safely.

Eligible kids for Stratum 1 are between 5-21 years, while Stratum 2 includes ages 3-21. This study involves frequent hospital visits and requires the head to be shaved for device use. Participants must not have certain medical devices or conditions that interfere with Optune. Parents or guardians must consent to the study, and participants must be willing to follow instructions carefully. The device may cause side effects, and its effectiveness varies.

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Study details
    Malignant Glioma
    Ependymoma
    Diffuse Intrinsic Pontine Glioma

NCT03033992

Pediatric Brain Tumor Consortium

27 April 2025

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