This study tests the effects of a weekly **Nimacimab** injection, alone or with **Semaglutide** (a medicine that helps with weight loss), on people who are obese or overweight with health issues related to their weight. A **placebo** (a fake treatment) is used for comparison. **Obesity** is when someone has too much body fat, and **comorbidities** are other health problems that come with it. You can join if you're 18-65, have a specific Body Mass Index (BMI), and meet other health criteria. You can't join if you have diabetes, certain health conditions, or if you're pregnant.
- Duration: The study involves ongoing injections once a week.
- Eligibility: Participants must be 18-65 years old with specific BMI criteria.
- Compensation: Participants may receive compensation for participation.
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