Image

Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

Studying Nivolumab with chemo-immunotherapy for new mediastinal B-cell lymphoma.

Recruiting
2 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study tests the combination of nivolumab with chemo-immunotherapy for treating Primary Mediastinal B-Cell Lymphoma (PMBCL), a type of blood cancer. Nivolumab is a medicine called a monoclonal antibody that helps the immune system fight cancer cells. The trial compares this combination to just chemo-immunotherapy, which includes drugs like rituximab that also help the immune system. The main goal is to see if the combination helps patients survive longer without the cancer coming back.

  • Study Length: 6 cycles of treatment, each lasting 21 days.
  • Visits and Tests: Involves regular hospital visits, blood tests, and scans like CT or PET.
  • Eligibility: Available for both kids (age 2+) and adults with specific health conditions.

Participants will be randomly assigned to different groups receiving different treatments. They will be closely monitored with tests and scans throughout the study. Follow-up visits will occur for several years after treatment to track progress and health.

Print
Study details
    Primary Mediastinal Large B-Cell Lymphoma

NCT04759586

National Cancer Institute (NCI)

11 May 2025

Contact a study center
Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.