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A Study to Investigate the Efficacy and Safety of Dupilumab Therapy Compared With Placebo in Participants Aged ≥18 Years With Moderately to Severely Active Ulcerative Colitis With an Eosinophilic Phenotype (LIBERTY-UC SUCCEED (Study in UC for Clinical Efficacy Evaluation of Dupilumab))

Exploring Dupilumab's effects on ulcerative colitis in adults.

Recruiting
18 years and older
All
Phase 2

This study is testing a new medicine called dupilumab for people 18 and older with a type of Ulcerative Colitis (UC), which is a condition that causes sores in the colon. The study will compare dupilumab to a placebo, which looks like the medicine but has no active ingredients. Participants must have a specific type of UC, where certain cells called eosinophils are involved.

The study lasts up to 68 weeks. It includes a 2 to 4-week screening period, a 52-week treatment period, and a 12-week follow-up. Those who qualify may also receive dupilumab openly during the study.

  • Participants will need to be involved for over a year, including multiple visits.
  • Dupilumab is compared to a placebo; participants might receive either.
  • There are specific criteria to join, and some medical conditions might exclude participation.

It’s important to talk to your doctor to see if this study is right for you and to understand all the risks and benefits. This summary does not include all details, so ask all your questions before deciding to join.

Study details
    Colitis Ulcerative

NCT05731128

Sanofi

1 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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