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Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension

Join a study testing a new cholesterol treatment.

Recruiting
18 years and older
All
Phase 3

Enlicitide Decanoate is a medicine for adults with hypercholesterolemia, a condition where there is too much cholesterol (a type of fat) in the blood. This study is to see if the medicine works well and is safe over a longer time. The study is only for people who have already completed one of three earlier studies on this medicine. If you finished one of the earlier studies and did well, you might be able to join. You should not join if you had to stop taking the medicine before or if you had a serious problem from it. Also, you cannot join if you plan to start other medicines called PCSK9 inhibitors or if you are part of another study.

  • The study will check long-term safety and effectiveness of the medicine.
  • You must have completed one of the earlier studies with at least 80% compliance.
  • You cannot join if you stopped the medicine before or are in another study.
Study details
    Hypercholesterolemia

NCT06492291

Merck Sharp & Dohme LLC

11 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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