The **Childhood Cancer Predisposition Study (CCPS)** is an observational study. **Observational** means they will watch and collect data without changing anything. **Cancer predisposition syndromes (CPS)** are conditions that make it more likely for someone to get cancer. The study collects clinical (medical) and biological (body) data from children with CPS and their families. This helps doctors understand cancer better and find ways to prevent and detect it early.
The study plans to enroll about 350 children and 700 relatives each year. They gather information when people join and check on them at least once a year. A **biorepository** (a place to store biological samples) will be set up at Emory University to keep tissue samples for future research.
- Younger than 21 years old can join if they have CPS, even if they haven't had cancer.
- Family members can also join if they are related to someone with CPS.
- Participation involves annual check-ins and might include giving tissue samples.