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Tocilizumab in Schizophrenia

Testing tocilizumab for potential benefits in schizophrenia.

Recruiting
18-55 years
All
Phase 1

This study tests if a drug called **Tocilizumab**, combined with usual medicines, helps people with schizophrenia, a brain disorder that affects thinking and emotions. Tocilizumab is already used to treat arthritis and works by blocking a protein called **IL-6** which can cause inflammation (swelling and irritation) in the body. The study lasts **12 weeks** and involves 20 patients who will receive either Tocilizumab or a placebo (a substance with no treatment effect) every 4 weeks. Patients will visit the clinic **6 times** over the study period to receive their infusions and for tests to check their thinking skills and any side effects.

  • The study involves 6 clinic visits over 12 weeks, with 3 infusions of the study drug.
  • Participants must be adults (18-55 years) with stable schizophrenia, already on certain medications.
  • Known side effects include headaches, high blood pressure, and possible infections.

Participants will be closely monitored and must not have recent infections or certain health conditions. The study is designed to see if reducing inflammation improves thinking skills in people with schizophrenia.

Study details
    Schizophrenia
    Psychotic Disorders

NCT02874573

Brian Miller

10 October 2024

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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