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Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology

Exploring new bladder cancer treatments with Enfortumab Vedotin and Pembrolizumab.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This clinical trial is for people with advanced bladder cancer. The study is testing two treatments: Enfortumab Vedotin and Pembrolizumab. Enfortumab Vedotin is a special medicine that finds cancer cells and helps destroy them. Pembrolizumab is a type of immunotherapy that helps the body’s immune system fight cancer. This study wants to see if these treatments together can shrink the cancer.

Key Points:

  • The study lasts up to 2 years, with regular doctor visits and tests like CT or MRI scans.
  • Participants must be at least 18 years old and have advanced bladder cancer.
  • Women must not be pregnant or breastfeeding, and both men and women must use birth control during the study.

The study will check how well the treatments work and if there are any side effects. Patients need to provide cancer tissue samples or agree to a biopsy. This study is for those who are willing to attend all visits and follow the study plan. If you are interested, talk to your doctor to see if you qualify.

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Study details
    Bladder Squamous Cell Carcinoma
    Locally Advanced Bladder Carcinoma
    Malignant Renal Pelvis Neoplasm
    Malignant Ureter Neoplasm
    Malignant Urethral Neoplasm
    Metastatic Bladder Carcinoma
    Stage III Bladder Cancer AJCC v8
    Stage IV Bladder Cancer AJCC v8
    Unresectable Bladder Carcinoma
    Urachal Adenocarcinoma
    Bladder Adenocarcinoma

NCT05756569

Emory University

13 December 2024

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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