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Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

Join our study on heart health with a new oral medication.

Recruiting
18 years and older
All
Phase 3

This study tests a new pill called enlicitide decanoate for people with high heart risk. It's a "PCSK9 inhibitor," which means it helps lower bad cholesterol (LDL) in your blood. The study will compare this new pill to a placebo (a fake pill with no medicine) to see if it can prevent heart problems like heart attacks, strokes, or surgeries.

Who can join? If you're 18 or older and have had heart issues like a heart attack, stroke, or leg artery surgery, or if you're at high risk of these problems, you might qualify. Also, your cholesterol levels and current treatments will be checked.

Who can't join? If you have certain genetic cholesterol problems, severe heart failure, or are taking specific cholesterol medications, you might not be able to join.

  • Study Length: Participants will be involved in the study for some time, but exact duration isn't specified.
  • Visits: You'll need to visit the study site for tests and check-ups.
  • Risks: As with any study, there might be risks, so discussing with your doctor is important.
Study details
    Arteriosclerosis
    Hypercholesterolaemia

NCT06008756

Merck Sharp & Dohme LLC

18 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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