This study is testing a combination of drugs called afuresertib and fulvestrant for people with advanced breast cancer. Breast cancer can spread to different parts of the body, which is called metastatic. The study is in two parts: Phase Ib and Phase III. Patients need to have tried 1 to 2 treatments before joining. Afuresertib and fulvestrant are being tested to see if they work well together and are safe for patients. This study lasts for several months. You must be 18 or older and have specific types of breast cancer to join. You will need to give a blood sample and might need a biopsy, which is when doctors take a small piece of tissue to look at it closely.
- Participation requires several visits and tests.
- There may be risks and side effects from the study drugs.
- Compensation details are not specified.
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