This study is testing a medicine called **lumateperone** for people with **bipolar mania**. Bipolar mania is when someone has extra energy, feels very happy, or has racing thoughts. The study lasts about **5 weeks** and includes three parts: a screening week to check if you can join, a 3-week treatment where you might get the medicine or a pretend pill (placebo), and a safety check week. To join, you must be 18-75 years old, agree to the rules, and be in the hospital because of a manic episode. If you have **other mental disorders** like schizophrenia, or have serious thoughts of harm, you can’t join.

• The study takes about 5 weeks in total.
• Participants must stay in the hospital during the study.
• The study checks for safety during and after the treatment period.