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Pembrolizumab, Capecitabine, and Radiation Therapy in Treating Patients With Mismatch-Repair Deficient and Epstein-Barr Virus Positive Gastric Cancer

Exploring new treatment options for specific gastric cancer types.

Recruiting
18 years and older
All
Phase 2

This study is looking at how a combination of treatments works for patients with a type of stomach cancer. The treatments are **pembrolizumab** (a monoclonal antibody that helps the immune system fight cancer), **capecitabine** (a chemotherapy drug that stops cancer cells from growing), and **radiation therapy** (high-energy x-rays to kill cancer cells). The study will see how well these treatments work together and check for any side effects. Patients will receive pembrolizumab every 3 weeks and may also have surgery and radiation.

  • **Study Length**: Treatment up to 1 year, with follow-ups for a few more years.
  • **Visits**: Regular visits for treatment and check-ups.
  • **Risks**: Possible side effects from drugs and radiation.

To participate, patients must have a specific type of stomach cancer that can be operated on, and they must meet certain health criteria. They cannot have other serious health issues, be pregnant, or be breastfeeding. This study aims to improve how stomach cancer is treated and support patients in their recovery.

Study details
    Epstein-Barr Virus Positive
    Gastric Adenocarcinoma
    Mismatch Repair Protein Deficiency
    Stage IB Gastric Cancer AJCC v7
    Stage II Gastric Cancer AJCC v7
    Stage IIA Gastric Cancer AJCC v7
    Stage IIB Gastric Cancer AJCC v7
    Stage III Gastric Cancer AJCC v7
    Stage IIIA Gastric Cancer AJCC v7
    Stage IIIB Gastric Cancer AJCC v7
    Stage IIIC Gastric Cancer AJCC v7

NCT03257163

Rutgers, The State University of New Jersey

13 December 2024

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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