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S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

Study comparing brain scans with or without radiation for lung cancer.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at treating small cell lung cancer (SCLC) with two different methods to prevent cancer from spreading to the brain. One method uses only Magnetic Resonance Imaging (MRI) scans, a type of picture that shows inside the body, to watch for cancer spread. The other method combines MRIs with Prophylactic Cranial Irradiation (PCI), a type of radiation therapy that targets the brain to stop cancer from spreading. The study wants to see if using just MRI scans is as good as using both MRI and PCI for patients' survival.

Key Points to Consider:

  • Patients will be randomly assigned to have either MRI scans alone or both MRI and PCI. MRI is done at 3, 6, 9, 12, 18, and 24 months.
  • This study requires patients to have a confirmed diagnosis of SCLC and no current or past brain cancer.
  • Participants must agree to use effective birth control during and after treatment, and those eligible must complete cognitive tests.
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Study details
    Extensive Stage Lung Small Cell Carcinoma
    Limited Stage Lung Small Cell Carcinoma
    Lung Small Cell Carcinoma

NCT04155034

SWOG Cancer Research Network

13 December 2024

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