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Cabozantinib in Combination With 13-cis-Retinoic Acid in Children With Relapsed or Refractory Solid Tumors

Exploring cabozantinib and retinoic acid for tough childhood tumors.

Recruiting
2-26 years
All
Phase 1

This study tests the safety of combining two medicines, **cabozantinib** and **13-cis-retinoic acid**, for children with hard-to-treat solid tumors. **Cabozantinib** is a drug that can help stop the growth of cancer cells, and **13-cis-retinoic acid** is a vitamin-like drug used to treat acne and some types of cancer. The study will find the best dose that patients can take safely.

Kids in the study must have a solid tumor not responding to standard treatments. They will take cabozantinib pills daily, with 13-cis-retinoic acid for 2 weeks each month. The treatment continues until the tumor grows or progresses. Patients will get check-ups every week for the first month, then monthly.

  • The study includes frequent medical check-ups, especially in the first month.
  • Participants must not have certain health conditions like severe heart problems.
  • Pregnant women cannot participate, and all participants must agree to use birth control.

Doctors will monitor the medicine's effects, and participants will continue if they respond well. It's important for families to consider the time commitment and health requirements before enrolling.

Study details
    Solid Tumor

NCT03611595

Peter Zage

12 October 2024

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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