Image

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-Small Cell Lung Cancer, ALCHEMIST Trial

Exploring immunotherapy with chemotherapy for non-small cell lung cancer.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing if adding a drug called **pembrolizumab** (a type of immunotherapy) to the regular chemotherapy treatment can help patients with non-small cell lung cancer (NSCLC). **Immunotherapy** is a treatment that helps the body’s immune system fight cancer. **Chemotherapy** uses strong medicines to kill or stop cancer cells from growing. In this study, patients with certain stages of NSCLC that has been removed by surgery will receive either pembrolizumab after chemotherapy or together with chemotherapy, to see if it helps them live longer without the cancer coming back.

  • Study Duration: The study involves regular treatments for up to 2 years, with follow-up visits for up to 10 years.
  • Visits: Regular doctor visits are required every few weeks initially, then less frequently for follow-up.
  • Risks: Possible side effects include those typical of chemotherapy and immunotherapy, like fatigue, nausea, or increased infections.

Eligibility includes being 18 years or older, having a specific stage of lung cancer, and not having certain other health issues. Before joining, discuss with your doctor to understand all potential benefits and risks.

Print
Study details
    Lung Non-Small Cell Carcinoma
    Lung Non-Small Cell Squamous Carcinoma
    Lung Non-Squamous Non-Small Cell Carcinoma
    Stage II Lung Cancer AJCC v8
    Stage IIIA Lung Cancer AJCC v8
    Stage IIIB Lung Cancer AJCC v8

NCT04267848

National Cancer Institute (NCI)

5 July 2025

Contact a study center
Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.